A divergent INS protein in Caenorhabditis elegans structurally resembles human insulin and activates the human insulin receptor

Caenorhabditis elegans contains a family of putative insulin-like genes proposed to regulate dauer arrest and senescence. These sequences often lack characteristic sequence features of human insulin essential for its folding, structure, and function. Here, we describe the structure and receptor-bind...

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Bibliografiske detaljer
Main Authors: Hua, Qing-xin, Nakagawa, Satoe H., Wilken, Jill, Ramos, Rowena R., Jia, Wenhua, Bass, Joseph, Weiss, Michael A.
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2003
Fag:
Research Communication
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC196032/
https://ncbi.nlm.nih.gov/pubmed/12654724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1058003
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