Retinoic Acid (RA) Regulates 17β-Hydroxysteroid Dehydrogenase Type 2 Expression in Endometrium: Interaction of RA Receptors with Specificity Protein (SP) 1/SP3 for Estradiol Metabolism

Context: The enzyme 17β-hydroxysteroid dehydrogenase type 2 (HSD17B2) exerts a local antiestrogenic effect by metabolizing biologically active estradiol to inactive estrone in endometrial epithelial cells. Retinoic acid (RA) induces HSD17B2 expression, but the underlying mechanism is not known. Obje...

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Autors principals: Cheng, You-Hong, Yin, Ping, Xue, Qing, Yilmaz, Bertan, Dawson, Marcia I., Bulun, Serdar E.
Format: Artigo
Idioma:Inglês
Publicat: The Endocrine Society 2008
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2386682/
https://ncbi.nlm.nih.gov/pubmed/18270252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jc.2007-1536
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