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MEL-18 ACTS AS A TUMOR SUPPRESSOR BY REPRESSING BMI-1 EXPRESSION AND DOWN-REGULATING AKT ACTIVITY IN BREAST CANCER CELLS

The Bmi-1 oncogene is overexpressed in a number of malignancies including breast cancer. In addition to Bmi-1, mammalian cells also express four other polycomb group (PcG) proteins that are closely related to Bmi-1. Virtually nothing is known about the role of these PcG proteins in oncogenesis. We h...

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Bibliografische gegevens
Hoofdauteurs: Guo, Wei-Jian, Zeng, Mu-Sheng, Yadav, Ajay, Song, Li-Bing, Guo, Bao-Hong, Band, Vimla, Dimri, Goberdhan P.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2007
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2386662/
https://ncbi.nlm.nih.gov/pubmed/17545584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-06-4368
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