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MEL-18 ACTS AS A TUMOR SUPPRESSOR BY REPRESSING BMI-1 EXPRESSION AND DOWN-REGULATING AKT ACTIVITY IN BREAST CANCER CELLS
The Bmi-1 oncogene is overexpressed in a number of malignancies including breast cancer. In addition to Bmi-1, mammalian cells also express four other polycomb group (PcG) proteins that are closely related to Bmi-1. Virtually nothing is known about the role of these PcG proteins in oncogenesis. We h...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2386662/ https://ncbi.nlm.nih.gov/pubmed/17545584 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-06-4368 |
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