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Mammary epithelial cell transformation: insights from cell culture and mouse models

Normal human mammary epithelial cells (HMECs) have a finite life span and do not undergo spontaneous immortalization in culture. Critical to oncogenic transformation is the ability of cells to overcome the senescence checkpoints that define their replicative life span and to multiply indefinitely –...

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Detalles Bibliográficos
Main Authors: Dimri, Goberdhan, Band, Hamid, Band, Vimla
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2005
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1175079/
https://ncbi.nlm.nih.gov/pubmed/15987472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr1275
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