Bmi-1 cooperates with H-Ras to transform human mammary epithelial cells via dysregulation of multiple growth regulatory pathways

Elevated expression of Bmi-1 is associated with many cancers including breast cancer. Here we examined the oncogenic potential of Bmi-1 in MCF10A cells, a spontaneously immortalized, nontransformed strain of human mammary epithelial cells (HMECs). Bmi-1 overexpression alone in MCF10A cells did not r...

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Main Authors: Datta, Sonal, Hoenerhoff, Mark J., Bommi, Prashant, Sainger, Rachana, Guo, Wei-Jian, Dimri, Manjari, Band, Hamid, Band, Vimla, Green, Jeffrey E., Dimri, Goberdhan P.
Formato: Artigo
Idioma:Inglês
Publicado: 2007
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2424172/
https://ncbi.nlm.nih.gov/pubmed/17974970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-07-1636
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