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BMI1 Cooperates with H-RAS to Induce an Aggressive Breast Cancer Phenotype with Brain Metastases
BMI1 is a member of the polycomb group of transcription repressors that functions in stem cell maintenance and oncogenesis through inhibition of the INK4A/ARF tumour suppressor locus. Overexpression of BMI1 is associated with poor prognosis in several human cancers, including breast cancer. We have...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2733922/ https://ncbi.nlm.nih.gov/pubmed/19543317 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2009.165 |
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