A Bacterial Cytotoxin Identifies the RhoA Exchange Factor Net1 as a Key Effector in the Response to DNA Damage

BACKGROUND: Exposure of adherent cells to DNA damaging agents, such as the bacterial cytolethal distending toxin (CDT) or ionizing radiations (IR), activates the small GTPase RhoA, which promotes the formation of actin stress fibers and delays cell death. The signalling intermediates that regulate R...

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Hlavní autoři: Guerra, Lina, Carr, Heather S., Richter-Dahlfors, Agneta, Masucci, Maria G., Thelestam, Monica, Frost, Jeffrey A., Frisan, Teresa
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2008
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2386254/
https://ncbi.nlm.nih.gov/pubmed/18509476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0002254
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