A Bacterial Cytotoxin Identifies the RhoA Exchange Factor Net1 as a Key Effector in the Response to DNA Damage

BACKGROUND: Exposure of adherent cells to DNA damaging agents, such as the bacterial cytolethal distending toxin (CDT) or ionizing radiations (IR), activates the small GTPase RhoA, which promotes the formation of actin stress fibers and delays cell death. The signalling intermediates that regulate R...

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Detalhes bibliográficos
Main Authors: Guerra, Lina, Carr, Heather S., Richter-Dahlfors, Agneta, Masucci, Maria G., Thelestam, Monica, Frost, Jeffrey A., Frisan, Teresa
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2008
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2386254/
https://ncbi.nlm.nih.gov/pubmed/18509476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0002254
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