The novel histone deacetylase inhibitor, LBH589, induces expression of DNA damage response genes and apoptosis in Ph(−) acute lymphoblastic leukemia cells

We investigated the mechanism of action of LBH589, a novel broad-spectrum HDAC inhibitor belonging to the hydroxamate class, in Philadelphia chromosome–negative (Ph(−)) acute lymphoblastic leukemia (ALL). Two model human Ph(−) ALL cell lines (T-cell MOLT-4 and pre–B-cell Reh) were treated with LBH58...

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Main Authors: Scuto, Anna, Kirschbaum, Mark, Kowolik, Claudia, Kretzner, Leo, Juhasz, Agnes, Atadja, Peter, Pullarkat, Vinod, Bhatia, Ravi, Forman, Stephen, Yen, Yun, Jove, Richard
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society of Hematology 2008
Ábhair:
Neoplasia
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2384136/
https://ncbi.nlm.nih.gov/pubmed/18349321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-10-117762
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