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Null mutations in human and mouse orthologs frequently result in different phenotypes
One-to-one orthologous genes of relatively closely related species are widely assumed to have similar functions and cause similar phenotypes when deleted from the genome. Although this assumption is the foundation of comparative genomics and the basis for the use of model organisms to study human bi...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2383943/ https://ncbi.nlm.nih.gov/pubmed/18458337 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0800387105 |
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