Leaky Ca(2+) release channel/ryanodine receptor 2 causes seizures and sudden cardiac death in mice

The Ca(2+) release channel ryanodine receptor 2 (RyR2) is required for excitation-contraction coupling in the heart and is also present in the brain. Mutations in RyR2 have been linked to exercise-induced sudden cardiac death (catecholaminergic polymorphic ventricular tachycardia [CPVT]). CPVT-assoc...

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Autores principales: Lehnart, Stephan E., Mongillo, Marco, Bellinger, Andrew, Lindegger, Nicolas, Chen, Bi-Xing, Hsueh, William, Reiken, Steven, Wronska, Anetta, Drew, Liam J., Ward, Chris W., Lederer, W.J., Kass, Robert S., Morley, Gregory, Marks, Andrew R.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2008
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2381750/
https://ncbi.nlm.nih.gov/pubmed/18483626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI35346
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