A functional GTP-binding motif is necessary for antiviral activity of Mx proteins.

Mx proteins are interferon-induced GTPases that inhibit the multiplication of certain negative-stranded RNA viruses. However, it has been unclear whether GTPase activity is necessary for antiviral function. Here, we have introduced mutations into the tripartite GTP-binding consensus elements of the...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Pitossi, F, Blank, A, Schröder, A, Schwarz, A, Hüssi, P, Schwemmle, M, Pavlovic, J, Staeheli, P
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1993
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC238112/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8411374/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.67.11.6726-6732.1993
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