Partial inhibition of the human immunodeficiency virus type 1 protease results in aberrant virus assembly and the formation of noninfectious particles.

The production of infectious particles by human immunodeficiency virus type 1 is dependent on the accurate cleavage of its Gag and Gag/Pol precursors by a virally encoded protease. In the absence of protease activity, morphologically abnormal particles which are noninfectious are formed. Recently, i...

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Vydáno v:J Virol
Hlavní autoři: Kaplan, A H, Zack, J A, Knigge, M, Paul, D A, Kempf, D J, Norbeck, D W, Swanstrom, R
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology (ASM) 1993
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC237772/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8510215/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.67.7.4050-4055.1993
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