Partial inhibition of the human immunodeficiency virus type 1 protease results in aberrant virus assembly and the formation of noninfectious particles.

The production of infectious particles by human immunodeficiency virus type 1 is dependent on the accurate cleavage of its Gag and Gag/Pol precursors by a virally encoded protease. In the absence of protease activity, morphologically abnormal particles which are noninfectious are formed. Recently, i...

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Autores principales: Kaplan, A H, Zack, J A, Knigge, M, Paul, D A, Kempf, D J, Norbeck, D W, Swanstrom, R
Formato: Artigo
Lenguaje:Inglês
Publicado: 1993
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC237772/
https://ncbi.nlm.nih.gov/pubmed/8510215
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