Partial inhibition of the human immunodeficiency virus type 1 protease results in aberrant virus assembly and the formation of noninfectious particles.
The production of infectious particles by human immunodeficiency virus type 1 is dependent on the accurate cleavage of its Gag and Gag/Pol precursors by a virally encoded protease. In the absence of protease activity, morphologically abnormal particles which are noninfectious are formed. Recently, i...
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| Udgivet i: | J Virol |
|---|---|
| Principais autores: | , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Microbiology (ASM)
1993
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC237772/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8510215/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.67.7.4050-4055.1993 |
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