Increased gastrin-releasing peptide (GRP) receptor expression in tumour cells confers sensitivity to [Arg(6),D-Trp(7,9),N(me)Phe(8)]-substance P (6–11)-induced growth inhibition

[Arg(6),D-Trp(7,9),N(me)Phe(8)]-substance P (6–11) (SP-G) is a novel anticancer agent that has recently completed phase I clinical trials. SP-G inhibits mitogenic neuropeptide signal transduction and small cell lung cancer (SCLC) cell growth in vitro and in vivo. Using the SCLC cell line series GLC1...

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Detalhes bibliográficos
Main Authors: Waters, C M, MacKinnon, A C, Cummings, J, Tufail-Hanif, U, Jodrell, D, Haslett, C, Sethi, T
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2003
Assuntos:
Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2377129/
https://ncbi.nlm.nih.gov/pubmed/12771999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6600957
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