Degree of tumour vascularity correlates with drug accumulation and tumour response upon TNF-α-based isolated hepatic perfusion

Isolated hepatic perfusion (IHP) with melphalan with or without tumour necrosis factor alpha (TNF-α) is currently performed in clinical trials in patients with hepatic metastases. Previous studies led to the hypothesis that the use of TNF-α in isolated limb perfusion causes specific destruction of t...

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Bibliographic Details
Main Authors: van Etten, B, de Vries, M R, van IJken, M G A, Lans, T E, Guetens, G, Ambagtsheer, G, van Tiel, S T, de Boeck, G, de Bruijn, E A, Eggermont, A M M, ten Hagen, T L M
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2003
Subjects:
Genetics and Genomics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2377047/
https://ncbi.nlm.nih.gov/pubmed/12610519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6600707
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