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Overproduction, purification, crystallization and preliminary X-ray analysis of human Fe65-PTB2 in complex with the amyloid precursor protein intracellular domain

Alzheimer’s disease is associated with typical brain deposits (senile plaques) that mainly contain the neurotoxic amyloid β peptide. This peptide results from proteolytic processing of the type I transmembrane protein amyloid precursor protein (APP). During this proteolytic pathway the APP intracell...

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Bibliografische gegevens
Hoofdauteurs: Radzimanowski, Jens, Beyreuther, Konrad, Sinning, Irmgard, Wild, Klemens
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: International Union of Crystallography 2008
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2376414/
https://ncbi.nlm.nih.gov/pubmed/18453713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1744309108009524
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