Irinotecan pharmacokinetics-pharmacodynamics: the clinical relevance of prolonged exposure to SN-38

We have shown previously that the terminal disposition half-life of SN-38, the active metabolite of irinotecan, is much longer than earlier thought. Currently, it is not known whether this prolonged exposure has any relevance toward SN-38-induced toxicity. Here, we found that SN-38 concentrations pr...

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Detalhes bibliográficos
Main Authors: Mathijssen, R H J, Verweij, J, Loos, W J, de Bruijn, P, Nooter, K, Sparreboom, A
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2002
Assuntos:
Clinical
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2376117/
https://ncbi.nlm.nih.gov/pubmed/12107833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6600447
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