A fully human anti-Ep-CAM scFv-beta-glucuronidase fusion protein for selective chemotherapy with a glucuronide prodrug

Monoclonal antibodies against tumour-associated antigens could be useful to deliver enzymes selectively to the site of a tumour for activation of a non-toxic prodrug. A completely human fusion protein may be advantageous for repeated administration, as host immune responses may be avoided. We have c...

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Библиографические подробности
Главные авторы: de Graaf, M, Boven, E, Oosterhoff, D, van der Meulen-Muileman, I H, Huls, G A, Gerritsen, W R, Haisma, H J, Pinedo, H M
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2002
Предметы:
Experimental Therapeutics
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2375299/
https://ncbi.nlm.nih.gov/pubmed/11875747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6600143
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