A monoclonal antibody-beta-glucuronidase conjugate as activator of the prodrug epirubicin-glucuronide for specific treatment of cancer.

The anti-pan carcinoma monoclonal antibody (MAb) 323/A3, linked to E. coli-derived beta-glucuronidase (GUS) was used to study the tumour-site-selective activation of the prodrug Epirubicin-glucuronide (Epi-glu). Epi-glu was isolated from the urine of patients treated with Epirubicin (Epi) by reverse...

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Bibliografische gegevens
Hoofdauteurs: Haisma, H. J., Boven, E., van Muijen, M., de Jong, J., van der Vijgh, W. J., Pinedo, H. M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 1992
Onderwerpen:
Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1977944/
https://ncbi.nlm.nih.gov/pubmed/1520585
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