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Methylation of hMLH1 promoter correlates with the gene silencing with a region-specific manner in colorectal cancer

Microsatellite instability is present in over 80% of the hereditary non-polyposis colorectal carcinoma and about 15–20% of the sporadic cancer. Microsatellite instability is caused by the inactivation of the mismatch repair genes, such as primarily hMLH1, hMSH2. To study the mechanisms of the inacti...

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Detalles Bibliográficos
Main Authors: Deng, G, Peng, E, Gum, J, Terdiman, J, Sleisenger, M, Kim, Y S
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2002
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2375277/
https://ncbi.nlm.nih.gov/pubmed/11870540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6600148
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