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Methylation of hMLH1 promoter correlates with the gene silencing with a region-specific manner in colorectal cancer
Microsatellite instability is present in over 80% of the hereditary non-polyposis colorectal carcinoma and about 15–20% of the sporadic cancer. Microsatellite instability is caused by the inactivation of the mismatch repair genes, such as primarily hMLH1, hMSH2. To study the mechanisms of the inacti...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group
2002
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2375277/ https://ncbi.nlm.nih.gov/pubmed/11870540 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6600148 |
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