Functioning of the dimeric GABA(B) receptor extracellular domain revealed by glycan wedge scanning

The G-protein-coupled receptor (GPCR) activated by the neurotransmitter GABA is made up of two subunits, GABA(B1) and GABA(B2). GABA(B1) binds agonists, whereas GABA(B2) is required for trafficking GABA(B1) to the cell surface, increasing agonist affinity to GABA(B1), and activating associated G pro...

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Main Authors: Rondard, Philippe, Huang, Siluo, Monnier, Carine, Tu, Haijun, Blanchard, Bertrand, Oueslati, Nadia, Malhaire, Fanny, Li, Ying, Trinquet, Eric, Labesse, Gilles, Pin, Jean-Philippe, Liu, Jianfeng
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2008
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2374841/
https://ncbi.nlm.nih.gov/pubmed/18388862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2008.64
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