Functioning of the dimeric GABA(B) receptor extracellular domain revealed by glycan wedge scanning

The G-protein-coupled receptor (GPCR) activated by the neurotransmitter GABA is made up of two subunits, GABA(B1) and GABA(B2). GABA(B1) binds agonists, whereas GABA(B2) is required for trafficking GABA(B1) to the cell surface, increasing agonist affinity to GABA(B1), and activating associated G pro...

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書誌詳細
主要な著者: Rondard, Philippe, Huang, Siluo, Monnier, Carine, Tu, Haijun, Blanchard, Bertrand, Oueslati, Nadia, Malhaire, Fanny, Li, Ying, Trinquet, Eric, Labesse, Gilles, Pin, Jean-Philippe, Liu, Jianfeng
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group 2008
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2374841/
https://ncbi.nlm.nih.gov/pubmed/18388862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2008.64
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