Pulmonary availability of isotretinoin in rats after inhalation of a powder aerosol

Repeated oral administration of chemopreventive retinoids such as isotretinoin over extended periods of time is associated with intolerable systemic toxicity. Here isotretinoin was formulated as a powder aerosol, and its delivery to the lungs of rats was studied with the aim to explore the possibili...

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Main Authors: Raleigh, S M, Verschoyle, R D, Bowskill, C, Pastorino, U, Staniforth, J N, Steele, F, Dinsdale, D, Carthew, P, Lim, C K, Silvester, J, Gescher, A
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2000
Fag:
Regular Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2374686/
https://ncbi.nlm.nih.gov/pubmed/10970697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1054/bjoc.2000.1421
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