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Pulmonary availability of isotretinoin in rats after inhalation of a powder aerosol
Repeated oral administration of chemopreventive retinoids such as isotretinoin over extended periods of time is associated with intolerable systemic toxicity. Here isotretinoin was formulated as a powder aerosol, and its delivery to the lungs of rats was studied with the aim to explore the possibili...
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| 主要な著者: | , , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group
2000
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2374686/ https://ncbi.nlm.nih.gov/pubmed/10970697 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1054/bjoc.2000.1421 |
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