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Experimental designs for phase I and phase I/II dose-finding studies
We review the rationale behind the statistical design of dose-finding studies as used in phase I and phase I/II clinical trials. We underline what the objectives of such dose-finding studies should be and why the widely used standard design fails to meet any of these objectives. The standard design...
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| Autores principales: | , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Nature Publishing Group
2006
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2374235/ https://ncbi.nlm.nih.gov/pubmed/16434987 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6602969 |
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