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Extended model-based designs for more complex dose-finding studies

We discuss extensions of model-based designs, such as the continual reassessment method, for use in dose-finding studies. Rather than work with a single model to carry out the design and analysis of a dose-finding study we indicate how the use of several models can greatly increase flexibility. We c...

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Detalhes bibliográficos
Main Authors: O’Quigley, John, Conaway, Mark
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3480175/
https://ncbi.nlm.nih.gov/pubmed/21351287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sim.4024
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