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Essential role of Notch signaling in effector memory CD8(+) T cell–mediated airway hyperresponsiveness and inflammation
Adoptive transfer of in vivo–primed CD8(+) T cells or in vitro–generated effector memory CD8(+) T (T(EFF)) cells restores airway hyperresponsiveness (AHR) and airway inflammation in CD8-deficient (CD8(−/−)) mice. Examining transcription levels, there was a strong induction of Notch1 in T(EFF) cells...
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| Autori principali: | , , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
The Rockefeller University Press
2008
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2373841/ https://ncbi.nlm.nih.gov/pubmed/18426985 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20072200 |
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