Essential role of Notch signaling in effector memory CD8(+) T cell–mediated airway hyperresponsiveness and inflammation

Adoptive transfer of in vivo–primed CD8(+) T cells or in vitro–generated effector memory CD8(+) T (T(EFF)) cells restores airway hyperresponsiveness (AHR) and airway inflammation in CD8-deficient (CD8(−/−)) mice. Examining transcription levels, there was a strong induction of Notch1 in T(EFF) cells...

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Main Authors: Okamoto, Masakazu, Takeda, Katsuyuki, Joetham, Anthony, Ohnishi, Hiroshi, Matsuda, Hiroyuki, Swasey, Christina H., Swanson, Bradley J., Yasutomo, Koji, Dakhama, Azzeddine, Gelfand, Erwin W.
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2008
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2373841/
https://ncbi.nlm.nih.gov/pubmed/18426985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20072200
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