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Two translocating hydrophilic segments of a nascent chain span the ER membrane during multispanning protein topogenesis

During protein integration into the endoplasmic reticulum, the N-terminal domain preceding the type I signal-anchor sequence is translocated through a translocon. By fusing a streptavidin-binding peptide tag to the N terminus, we created integration intermediates of multispanning membrane proteins....

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Hlavní autoři: Kida, Yuichiro, Morimoto, Fumiko, Sakaguchi, Masao
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2007
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2373506/
https://ncbi.nlm.nih.gov/pubmed/18166653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200707050
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