Mechanism of botulinum neurotoxin B and G entry into hippocampal neurons

Botulinum neurotoxins (BoNTs) target presynaptic nerve terminals by recognizing specific neuronal surface receptors. Two homologous synaptic vesicle membrane proteins, synaptotagmins (Syts) I and II, bind toxins BoNT/B and G. However, a direct demonstration that Syts I/II mediate toxin binding and e...

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Detalhes bibliográficos
Main Authors: Dong, Min, Tepp, William H., Liu, Huisheng, Johnson, Eric A., Chapman, Edwin R.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2007
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2373501/
https://ncbi.nlm.nih.gov/pubmed/18158333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200707184
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