Synoviolin promotes IRE1 ubiquitination and degradation in synovial fibroblasts from mice with collagen-induced arthritis

The E3 ubiquitin ligase synoviolin (SYVN1) functions as an anti-apoptotic factor that is responsible for the outgrowth of synovial cells during the development of rheumatoid arthritis. The molecular mechanisms underlying SYVN1 regulation of cell death are largely unknown. Here, we report that elevat...

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Detalles Bibliográficos
Main Authors: Gao, Beixue, Lee, Sang-Myeong, Chen, An, Zhang, Jinping, Zhang, Donna D, Kannan, Krishnaswamy, Ortmann, Robert A, Fang, Deyu
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2008
Assuntos:
Scientific Report
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2373369/
https://ncbi.nlm.nih.gov/pubmed/18369366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2008.37
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