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The proinflammatory cytokines IL-1β and TNF-α induce the expression of Synoviolin, an E3 ubiquitin ligase, in mouse synovial fibroblasts via the Erk1/2-ETS1 pathway

The overgrowth of synovial tissues is critical in the pathogenesis of rheumatoid arthritis (RA). The expression of Synoviolin (SYN), an E3 ubiquitin ligase, is upregulated in arthritic synovial fibroblasts and is involved in the overgrowth of synovial cells during RA. However, the molecular mechanis...

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Bibliografske podrobnosti
Main Authors: Gao, Beixue, Calhoun, Karen, Fang, Deyu
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2006
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1794516/
https://ncbi.nlm.nih.gov/pubmed/17105652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar2081
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