Functional dissection of siRNA sequence by systematic DNA substitution: modified siRNA with a DNA seed arm is a powerful tool for mammalian gene silencing with significantly reduced off-target effect

類似資料

• Thermodynamic stability and Watson–Crick base pairing in the seed duplex are major determinants of the efficiency of the siRNA-based off-target effect
  著者:: Ui-Tei, Kumiko, 等
  出版事項: (2008)
• Guidelines for the selection of highly effective siRNA sequences for mammalian and chick RNA interference
  著者:: Ui-Tei, Kumiko, 等
  出版事項: (2004)
• RNAi induced in mammalian and Drosophila cells via transfection of dimers and trimers of small interfering RNA
  著者:: Ui-Tei, Kumiko, 等
  出版事項: (2005)
• Distinguishable in vitro binding mode of monomeric TRBP and dimeric PACT with siRNA.
  著者:: Tomoko Takahashi, 等
  出版事項: (2013-01-01)
• Distinguishable In Vitro Binding Mode of Monomeric TRBP and Dimeric PACT with siRNA
  著者:: Takahashi, Tomoko, 等
  出版事項: (2013)