The initiation factor eIF3-f is a major target for Atrogin1/MAFbx function in skeletal muscle atrophy

In response to cancer, AIDS, sepsis and other systemic diseases inducing muscle atrophy, the E3 ubiquitin ligase Atrogin1/MAFbx (MAFbx) is dramatically upregulated and this response is necessary for rapid atrophy. However, the precise function of MAFbx in muscle wasting has been questioned. Here, we...

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Hauptverfasser: Lagirand-Cantaloube, Julie, Offner, Nicolas, Csibi, Alfredo, Leibovitch, Marie P, Batonnet-Pichon, Sabrina, Tintignac, Lionel A, Segura, Carlos T, Leibovitch, Serge A
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2008
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2367397/
https://ncbi.nlm.nih.gov/pubmed/18354498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2008.52
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