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The initiation factor eIF3-f is a major target for Atrogin1/MAFbx function in skeletal muscle atrophy
In response to cancer, AIDS, sepsis and other systemic diseases inducing muscle atrophy, the E3 ubiquitin ligase Atrogin1/MAFbx (MAFbx) is dramatically upregulated and this response is necessary for rapid atrophy. However, the precise function of MAFbx in muscle wasting has been questioned. Here, we...
में बचाया:
| मुख्य लेखकों: | , , , , , , , |
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| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
Nature Publishing Group
2008
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2367397/ https://ncbi.nlm.nih.gov/pubmed/18354498 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2008.52 |
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