The Translation Regulatory Subunit eIF3f Controls the Kinase-Dependent mTOR Signaling Required for Muscle Differentiation and Hypertrophy in Mouse

The mTORC1 pathway is required for both the terminal muscle differentiation and hypertrophy by controlling the mammalian translational machinery via phosphorylation of S6K1 and 4E-BP1. mTOR and S6K1 are connected by interacting with the eIF3 initiation complex. The regulatory subunit eIF3f plays a m...

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Detalhes bibliográficos
Main Authors: Csibi, Alfredo, Cornille, Karen, Leibovitch, Marie-Pierre, Poupon, Anne, Tintignac, Lionel A., Sanchez, Anthony M. J., Leibovitch, Serge A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2813880/
https://ncbi.nlm.nih.gov/pubmed/20126553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0008994
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