Translation initiation complex eIF4F is a therapeutic target for dual mTOR kinase inhibitors in non-Hodgkin lymphoma

Deregulated mRNA translation has been implicated in disease development and in part is controlled by a eukaryotic initiation complex eIF4F (composed of eIF4E, eIF4G and eIF4A). We demonstrate here that the cap bound fraction from lymphoma cells was enriched with eIF4G and eIF4E indicating that lymph...

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Vydáno v:Oncotarget
Hlavní autoři: Demosthenous, Christos, Han, Jing Jing, Stenson, Mary J., Maurer, Matthew J., Wellik, Linda E., Link, Brian, Hege, Kristen, Dogan, Ahmet, Sotomayor, Eduardo, Witzig, Thomas, Gupta, Mamta
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2015
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4496233/
https://ncbi.nlm.nih.gov/pubmed/25839159
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