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Mutations affecting a putative MutLα endonuclease motif impact multiple mismatch repair functions
Mutations in DNA mismatch repair (MMR) lead to increased mutation rates and higher recombination between similar, but not identical sequences, as well as resistance to certain DNA methylating agents. Recently, a component of human MMR machinery, MutLα, has been shown to display a latent endonuclease...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2366940/ https://ncbi.nlm.nih.gov/pubmed/17567544 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2007.04.013 |
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