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Mutations affecting a putative MutLα endonuclease motif impact multiple mismatch repair functions

Mutations in DNA mismatch repair (MMR) lead to increased mutation rates and higher recombination between similar, but not identical sequences, as well as resistance to certain DNA methylating agents. Recently, a component of human MMR machinery, MutLα, has been shown to display a latent endonuclease...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Erdeniz, Naz, Nguyen, Megan, Deschênes, Suzanne M., Liskay, R. Michael
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2007
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2366940/
https://ncbi.nlm.nih.gov/pubmed/17567544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2007.04.013
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