Characterization of human immunodeficiency virus type 1 variants with increased resistance to a C2-symmetric protease inhibitor.

Inhibitors of the human immunodeficiency virus type 1 protease represent a promising class of antiviral drugs for the treatment of AIDS, and several are now in clinical trials. Here, we report the in vitro selection of viral variants with decreased sensitivity to a C2-symmetric protease inhibitor (A...

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發表在:	J Virol
Principais autores:	Ho, D D, Toyoshima, T, Mo, H, Kempf, D J, Norbeck, D, Chen, C M, Wideburg, N E, Burt, S K, Erickson, J W, Singh, M K
格式:	Artigo
語言:	Inglês
出版:	American Society for Microbiology (ASM) 1994
主題:	Research Article
在線閱讀:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC236669/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8107264/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.68.3.2016-2020.1994
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