Characterization of human immunodeficiency virus type 1 variants with increased resistance to a C2-symmetric protease inhibitor.

Inhibitors of the human immunodeficiency virus type 1 protease represent a promising class of antiviral drugs for the treatment of AIDS, and several are now in clinical trials. Here, we report the in vitro selection of viral variants with decreased sensitivity to a C2-symmetric protease inhibitor (A...

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Pubblicato in:	J Virol
Autori principali:	Ho, D D, Toyoshima, T, Mo, H, Kempf, D J, Norbeck, D, Chen, C M, Wideburg, N E, Burt, S K, Erickson, J W, Singh, M K
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1994
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC236669/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8107264/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.68.3.2016-2020.1994
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