Antigen Load and Viral Sequence Diversification Determine the Functional Profile of HIV-1–Specific CD8(+) T Cells

BACKGROUND: Virus-specific CD8(+) T lymphocytes play a key role in the initial reduction of peak viremia during acute viral infections, but display signs of increasing dysfunction and exhaustion under conditions of chronic antigen persistence. It has been suggested that virus-specific CD8(+) T cells...

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Main Authors: Streeck, Hendrik, Brumme, Zabrina L, Anastario, Michael, Cohen, Kristin W, Jolin, Jonathan S, Meier, Angela, Brumme, Chanson J, Rosenberg, Eric S, Alter, Galit, Allen, Todd M, Walker, Bruce D, Altfeld, Marcus
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2008
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2365971/
https://ncbi.nlm.nih.gov/pubmed/18462013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pmed.0050100
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