Human Immunodeficiency Virus Type 1-Specific CD8(+) T-Cell Responses during Primary Infection Are Major Determinants of the Viral Set Point and Loss of CD4(+) T Cells

Primary HIV-1 infection (PHI) is marked by a flu-like syndrome and high levels of viremia that decrease to a viral set point with the first emergence of virus-specific CD8(+) T-cell responses. Here, we investigated in a large cohort of 527 subjects the immunodominance pattern of the first virus-spec...

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Main Authors: Streeck, Hendrik, Jolin, Jonathan S., Qi, Ying, Yassine-Diab, Bader, Johnson, Randall C., Kwon, Douglas S., Addo, Marylyn M., Brumme, Chanson, Routy, Jean-Pierre, Little, Susan, Jessen, Heiko K., Kelleher, Anthony D., Hecht, Frederick M., Sekaly, Rafick-Pierre, Rosenberg, Eric S., Walker, Bruce D., Carrington, Mary, Altfeld, Marcus
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2009
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2708622/
https://ncbi.nlm.nih.gov/pubmed/19458000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00182-09
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