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siRNA knockdown of PD-L1 and PD-L2 in monocyte-derived dendritic cells only modestly improves proliferative responses to Gag by CD8(+) T cells from HIV-1 infected individuals
Due to their capacity to elicit and regulate immunity, dendritic cells (DCs) are important targets to improve vaccination. Knowing that PD-1 high virus-specific T cells become functionally exhausted during chronic exposure to HIV-1, the development of a therapeutic DC-based HIV-1 vaccine might inclu...
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| Autori principali: | , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2009
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2933267/ https://ncbi.nlm.nih.gov/pubmed/19562472 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10875-009-9313-9 |
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