siRNA knockdown of PD-L1 and PD-L2 in monocyte-derived dendritic cells only modestly improves proliferative responses to Gag by CD8(+) T cells from HIV-1 infected individuals

Due to their capacity to elicit and regulate immunity, dendritic cells (DCs) are important targets to improve vaccination. Knowing that PD-1 high virus-specific T cells become functionally exhausted during chronic exposure to HIV-1, the development of a therapeutic DC-based HIV-1 vaccine might inclu...

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Bibliografiska uppgifter
Huvudupphovsmän: Breton, Gaëlle, Yassine-Diab, Bader, Cohn, Lillian, Boulassel, Mohamed-Rachid, Routy, Jean-Pierre, Sékaly, Rafick-Pierre, Steinman, Ralph M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2009
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2933267/
https://ncbi.nlm.nih.gov/pubmed/19562472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10875-009-9313-9
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