Synthesis, Structure and Biological Activity of 6-R(3)Si(Ge, Sn)-Substituted 5-Fluorouracils

Direct lithiation of 1-(2-tetrahydrofuryl)-5-fluorouracil (Ftorafur) has been investigated. The treatment of ftorafur with lithium diisopropylamide (LDA)at –70℃ in ether-hexane, followed by the reaction with various electrophiles afforded the corresponding 6-substituted silicon, germanium and tin de...

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Detalhes bibliográficos
Main Authors: Lukevics, E., Ignatovich, L., Shilina, N., Kemme, A., Sjakste, N.
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 1994
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2364875/
https://ncbi.nlm.nih.gov/pubmed/18476217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/MBD.1994.65
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