The relationship between radiation-induced G(1)arrest and chromosome aberrations in Li-Fraumeni fibroblasts with or without germline TP53 mutations

We previously showed that cultured fibroblasts from patients with the cancer-prone Li-Fraumeni (LF) syndrome, having heterozygous germline TP53 mutations, sustain less ionizing radiation-induced permanent G(1) arrest than normal fibroblasts. In contrast, fibroblast strains from LF patients without T...

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Bibliographic Details
Main Authors: Boyle, J M, Spreadborough, A, Greaves, M J, Birch, J M, Varley, J M, Scott, D
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2001
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Regular Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2364041/
https://ncbi.nlm.nih.gov/pubmed/11461092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1054/bjoc.2001.1896
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