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The ratio of single- to double-strand DNA breaks and their absolute values determine cell death pathway
Bleomycin is a cytotoxic antibiotic that generates DNA double-strand breaks (DSB) and DNA single-strand breaks (SSB). It is possible to introduce known quantities of bleomycin molecules into cells. Low amounts kill the cells by a slow process termed mitotic cell death, while high amounts produce a f...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group
2001
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2363894/ https://ncbi.nlm.nih.gov/pubmed/11336481 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1054/bjoc.2001.1786 |
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